The sensation of pain is caused by the release of a chemical called prostaglandin that stimulates the nerve endings and sends an electrical
message to the brain. Inhibiting the formation of prostaglandin reduces pain
and aspirin inhibits the formation of prostaglandin. When we experience the
sensation of pain it is likely that something is happening that the brain needs
to know about, so it can direct us to whatever damage-limiting action is
needed. We feel pain of hurt because we have genes that constructed a body able
to feel pain.
Without such a mechanism it is likely that life would be much shorter, with
less opportunity to pass on our genetic code. Therefore, being able to feel
pain is a state of affairs favorable to the continuing success of the species.
This is unlikely to be foremost in the thoughts of someone who has just broken
their leg or poured boiling water over their foot, but the fact remains that
feeling pain is part of the defenses that enable us to stay alive.
Drugs such as aspirin act at the site of the injury to stop or at least reduce
the production of messenger chemicals that stimulate the nerve endings. Aspirin
acts at the site of damaged tissue to block the start of the nerve signal to
the brain, the mechanism by which we experience pain. It does this by
inhibiting the formation of prostaglandin which is the active agent responsible
for the sensitization of the nerve endings.
Prostaglandins (there are several related types) are responsible for a lot of
physiological events in addition to the start of the pain signal at the nerve
ending. For example, they are responsible for inflammation, fever and the
clotting of platelets in the blood, so it is easy to see why aspirin is such a
useful drug. However, a prostaglandin also increases the formation of
protective mucus in the gut, so aspirin-induced suppression of its formation
can cause irritation and bleeding.
Any advice on how much aspirin to take? and in what intervals? I am willing to try as I have had several meds and have failed all. I’m looking at possible surgery either radiation or MVD. Has anyone had the radiofreqency surgery or MVD? any success ?
Hi Verdia, Sorry my mom suffers a lot even after Cyber Knife Radio Frequency Rizatomy, she is better with tablets now. Our doctor describes the procedure of radiation in never may cause some irritations to the nerve. These procedures (MVD or RF) may differ for everyone, and it depends upon the pain severeness and treatment method. Discuss a lot with your neuro doctors before go in for any procedures…
All the Best…
Hi Verdia, i know they’ve used Aspirin Intraveneously to aide Migraine sufferers with Withdrawels from Medications - and I’ve been using Aspirin while I’ve been reducing Tegretol and I definately think it helps - I take two a day myself, + more when I’m feeling yucky - but (as always) think people should have a chat with their doctor for advice about dosage.
I used to take paracetamol all the time and find that Aspirin seems to be much more effective alongside these TN meds. (I take tegretol and topamax myself).
Here’s an article you may be interested in:
This article is also quite interesting about the history of Aspirin:
Verdia Dora said:
Any advice on how much aspirin to take? and in what intervals? I am willing to try as I have had several meds and have failed all. I'm looking at possible surgery either radiation or MVD. Has anyone had the radiofreqency surgery or MVD? any success ?
We all understand we need to feel pain to know that something in our body is wrong. Though with TN it is very difficult to control, though it won’t kill us. Asprin is a no no for a lot of people as it can irritate the stomach and cause problems. TN is a very painful condition it can drive you almost insane with pain, sites like this are so necessary as they let you have a good old moan to other sufferers who understand and know that you need to let off steam to survive . Some people like Bob can also make you laugh even when the pain is at it’s worst. To think that I might live a long time with this pain. Oh dear Oh dear that thought has depressed me for the day. Where are you Bob I need to be cheered up. Margaret.